EMBO workshop

Genome instability is a hallmark of human tumours and the underlining cause of several human syndromes. A central axis in the maintenance of genomic stability is the DNA damage response (DDR) – a complex signalling network that is activated most vigorously by critical DNA lesions such as double strand breaks (DSBs). The network spans DNA repair, damage tolerance pathways and cell cycle checkpoints, and modulates numerous processes impacting oncellular metabolism. It is not surprising, therefore, that several major players in the DDR are tumour suppressors, andthat germ-line mutations affecting DDR players lead to inherited predisposition to cancer, or more complex genomic instability syndromes including sporadic cancers.

Read more: EMBO workshop

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens

 

Biomedical Research Foundation of the Academy of Athens

 

Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester

 

EMBO member

 

SenTraGorΤΜ

 

 

 

Office Tel: 0030 210-7462352
Fax: 0030 210-7462340
E-mail: [email protected]

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