Major Achievements

Our group played a major role in:

i) Establishing the “Oncogene-induced DNA damage model for cancer development” (Science 2008; Nat Rev Mol Cell Biol 2010) (Figures 1, 2, 5). Based on: Nature 2005; Nature 2006; J Pathol 2006; Cancer Res 2007; Oncogene 2008; Blood 2008; Am J Pathol 2009; Cancer Res 2012; Cell Death Differ 2014; Cell Mol Life Sci 2014; Cell Rep 2015; Nat Cell Biol 2016; and currently the broader role of DNA Damage response pathway in disease development (Cell 2016, in press).

ii) Demonstrating that oncogene-induced senescence is a DNA damage stress response acting as a barrier to cancer (Nature 2006; Cancer Res 2007; Am J Pathol 2009; Curr Opin Cell Biol 2010; Nature Genetics 2011; Nature Cell Biol 2011; Cell Death Differ 2015) (Figure 2).

iii) Clarifying the functional interplay and the timeline of events underlying the two major antitumor checkpoint responses, i.e. DDR and ARF (Nat Cell Biol 2013; Cell Death Diff 2013; Cell Cycle 2014) (Figure 2).

iv) Revealing the oncogenic role of replication licensing factors Cdc6 and Cdt1 by inducing DNA replication stress and deregulating transcription (Am J Path 2004; Nature 2006; Cancer Res 2007, J Cell Biol 2011; Transcription 2012; Semin Cancer Biol 2016; Nat Commun 2016; Nat Cell Biol 2016; PNAS 2016) (Figures 2, 3, 4).

v) Contributing to our understanding of the role that inflammation plays in cancer development (Cancer Cell 2013; Cancer Cell 2014; Pharmacol Ther 2015; Cell Rep 2016)

vi) Understanding how cellular senescence and molecules/pathways involved in senescence contribute to organismal development, aging and diverse pathologies, including cancer (EMBO J 2003; Lab Invest 2005; Nature 2006; Am J Pathol 2009; Mech Ageing Dev 2016; Aging 2013; Aging Cell 2013; Stem Cells 2013; Cell Death Differ 2015; Mech Ageing Dev 2016). As available assays to detect senescent cells are unsatisfactory, particularly in vivo, a major aim is to develop new methods to detect with precision and sensitivity senescent cells (Aging 2013; Aging Cell 2016).

1. Mechanisms leading to genomic instability

Nat Rev Mol Cell Biol 2010

2. The role of the DNA damage response (DDR) pathway as an anti-tumor barrier

Science 2008
Nature 2005
Nature 2006
Nature Cell Biol 2013

3. The role of Cdc6 in cancer progression

Am J Pathol 2004
Cancer Res 2007
J Cell Biol 2011
Transcription 2012

4. Oncogenic Cdc6 as a molecular switch during cancer development

J Cell Biol 2011
Transcription 2012

5. Prolonged expression of p21WAF1/Cip1 in p53-null cells as a driving force for cancer progression

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Nat Cell Biol 2016

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens

 

Biomedical Research Foundation of the Academy of Athens

 

Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester

 

EMBO member

 

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Fax: 0030 210-7462340
E-mail: [email protected]

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