Nefeli Lagopati

BSc, PhD

Research Interests

• Apoptotic effect and anticancer activity of nanomaterials in breast cancer
• Synthesis and chemical doping of nanomaterials
• Molecular mechanisms of intracellular signal transduction through redox cysteine residue modifications: the role of iron ions
• Oxidative stress, S-Glutathionylation
• Development of advanced biomaterials based on chitosan, for surgical applications / regenerative medicine
• Radiobiology and cytogenetics (chromosomal abnormalities post irradiation using ionizing radiation) and personalized radiotherapy based on patient specific radiosensitivity index estimation
• Dosimetry in Nuclear Medicine (palliative treatment for skeletal metastasis, liver cancer, myocardium stress/rest tests, differentiation and grading of Essential Tremor and Parkinsonism), Monte Carlo simulations, Image Reconstruction

My research activity is focused on biomedical issues, related to cancer. Medical physics, nanotechnology, radiobiology and material science are an important part of my research interests.

Selected Publications:

• N. Lagopati, E.-P. Tsilibary, P. Falaras, P. Papazafiri, E.A. Pavlatou., E. Kotsopoulou, P. Kitsiou, «Effect of nanostructured TiO2 crystal phase on photoinduced apoptosis of breast cancer epithelial cells», International Journal of Nanomedicine, 2014, 9 (1), 3219 - 3230. 

Link: https://www.ncbi.nlm.nih.gov/pubmed/

• N. Lagopati, P.V. Kitsiou, A.I. Kontos, P. Venieratos, E. Kotsopoulou, A.G. Kontos, D.D. Dionysiou, S. Pispas, E.C. Tsilibary, P. Falaras, «Photo-induced treatment of breast epithelial cancer cells using nanostructured titanium dioxide solution», Journal of Photochemistry and Photobiology A: Chemistry, 2010, 214 (2-3), 215-223.

Link: http://www.sciencedirect.com/science/article/pii/S1010603010002509

• I. Vamvakas, N. Lagopati, M. Andreou, M. Sotiropoulos, A. Gatzis, G. Limouris, C. Antypas, M. Lyra, «Patient specific computer automated dosimetry calculations during therapy with 111 In Octreotide», European Journal of Radiography, 2009, 1 (4), 180-183.

Link: http://www.sciencedirect.com/science/article/pii/S1756117510000285

• M. Lyra, N. Lagopati, P. Charalabatou, I. Vamvakas, «Patient - specific dosimetry in radionuclide therapy», Radiation Protection Dosimetry, 2011, 147, 258-263.

Link: https://www.ncbi.nlm.nih.gov/pubmed/

• M. Argyrou, M. Andreou, N. Lagopati, I. Baka, I. Vamvakas, M. Lyra, «A comparison of patient specific dosimetric calculations obtained by planar images and Monte Carlo simulation in 111 In octreotide therapy», Physica Medica, European Journal of Medical Physics, 2014, 30, Sup 1, e29.

Link: http://www.sciencedirect.com/science/article/pii/S1120179714002580

• M. Andreou, N. Lagopati, M. Lyra, «Re-186 and Sm-153 dosimetry based on scintigraphic imaging data in skeletal metastasis palliative treatment and Monte Carlo simulation», Journal of Physics, 2011, Ser 317, 1-4.

Link: http://iopscience.iop.org/article/10.1088/1742-6596/317/1/012013

• M.E. Lyra , M. Andreou, A.Georgantzoglou, S.D. Kordolaimi, N. Lagopati, A. Plousi, A.- L. N. Salvara, I. Vamvakas, «Radionuclides used in Nuclear Medicine Therapy – From Production to Dosimetry» Bentham Science Publishers, Current Medical Imaging Reviews, 2013, 9, 51-75.

Link: http://benthamsciencepublishers.org/journal/

• M. Lyra, M. Andreou, A. Georgantzoglou, S. Kordolaimi, N. Lagopati, A. Ploussi, A.-L. Salvara, I. Vamvakas, «Nuclear Medicine Therapy - Radioisotopes Production and Dosimetry», 2011, 1-52.

Link: http://eclass.uoa.gr/modules/

• M.E. Lyra, N. Lagopati, M. Sotiropoulos, Ch. Chatzigiannis and M. Gavrilelli, «The impact of scattering and peak spectrum of I-123 in scintigraphy by I-123 MIBG», Advanced Topics in Scattering Theory and Biomedical Engineering, Editors: A. Charalambopoulos, D.E.Fotiadis, D. Polyzos, World Scientific, 79-89, 2009.

Link: https://www.scopus.com/

Conference Proceedings:

• M. Lyra, J. Striligas, M. Gavrilleli, N. Lagopati., Volume Quantification of I-123 DaTSCAN Imaging by MatLab for the Differentiation and Grading of Parkinsonism and Essential Tremor, International Conference on Science and Social Research (Kuala Lumpur, Malaysia, December 5-7, 2010), 1, 163-168.

Link: http://ieeexplore.ieee.org/document/5773757/

• N. Lagopati, M. Andreou, M. Lyra, «Scintigraphic imaging data in skeletal metastasis treatment and Monte Carlo simulation, Re-186 and Sm-153 dosimetry», eProceedings of the International Conference "Image Optimisation in Nuclear Medicine" (OptiNM2011), Ayia Napa, Cyprus, March 23 - 26, 2011.

Link: http://iopscience.iop.org/article/10.1088/1742-6596/317/1/012013/meta

• M. Lyra, M. Sotiropoulos, N. Lagopati and M. Gavrilleli, «Quantification of myocardial perfusion in 3D SPECT images - stress/rest volume differences», 31 – 35, 2010.

Link: http://ieeexplore.ieee.org/document/5548486/

• M. Sotiropoulos, A. Zygogianni, N. Lagopati, C. Antypas, C. Arbillia, J. Kouvaris and M. E. Lyra, «Radiation Effects Quantification in Breast Radiotherapy by Mammography Image Processing» IFMBE Proceedings, Dössel Olaf – Schlegel Wolfgang C., Viol 25/5, 362-364, Springer, 2009.

Link: http://link.springer.com/

• ME Lyra, N Lagopati, P Charalabatou, E. Vasoura, A. Antoniou, C. Georgosopoulos, K. Skouroliakou, "Texture characterization in ultasonograms of the thyroid gland", 2010, 10th IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB), 2010, pp.1-4

Link: http://ieeexplore.ieee.org/document/5687628/