Oncogenic Cdc6 as a molecular switch during cancer development
Model describing the ability of oncogenic Cdc6 to act as a molecular switch. (a and b) Cdc6 acting as a molecular switch at the CDH1 (E-cadherin) (a) and INK4/ARF (b) locus (see Discussion in ref 1). Ori: replication origin.
1) Sideridou et al. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol 2011, 195(7): 1123-40.