Model describing the ability of oncogenic Cdc6 to act as a molecular switch. (a and b) Cdc6 acting as a molecular switch at the CDH1 (E-cadherin) (a) and INK4/ARF (b) locus (see Discussion in ref 1). Ori: replication origin.
1) Sideridou et al. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol 2011, 195(7): 1123-40.
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Prof. Vassilis G. Gorgoulis
Laboratory of Histology-Embryology
Chair of Clinical Molecular Pathology, Ninewells Hospital and School of Medicine
University of Dundee, Dundee, UK
Biomedical Research Foundation of the Academy of Athens
Faculty Institute for Cancer Sciences, University of Manchester, Manchester Centre for Cellular Metabolism,
EMBO member
European Academy
Academia Europaea member
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