The non cell-autonomous role of mutant p53 gain-of-function: reprogramming the microenvironment

Colon cancers cells harboring mutations in TP53 release exosomes that contain miR1246 which in turn are received by surrounding macrophages. The latter alter their phenotypic features, leading to secretion of anti-inflammatory cytokines along with factors implicated in epithelial and mesenchymal transition (EMT), which fuel tumorigenesis in this setting  (1, 2).

1) Cooks et al. When mutant p53 fires up. Cancer Cell & Microenvironment 2014, 1: e135.

2) Cooks et al. Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. Nat Commun 2018, 9(1): 771.

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens



Chair of Clinical Molecular Pathology,

Ninewells Hospital and School of Medicine


University of Dundee, Dundee, UK


Biomedical Research Foundation of the Academy of Athens


Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester


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of Cancer Sciences member


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