Cellular Senescence: Defining a Path Forward

The Hallmarks of the Senescence Phenotype. Senescent cells exhibit the following four interdependent hallmarks: cell-cycle withdrawal, macromolecular damage, secretory phenotype (SASP), and deregulated metabolism (1).

1) Gorgoulis et al. Cellular Senescence: Defining a Path Forward. Cell 2019, 179(4):813-827.