The Hallmarks of the Senescence Phenotype. Senescent cells exhibit the following four interdependent hallmarks: cell-cycle withdrawal, macromolecular damage, secretory phenotype (SASP), and deregulated metabolism (1).
1) Gorgoulis et al. Cellular Senescence: Defining a Path Forward. Cell 2019, 179(4):813-827.
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Prof. Vassilis G. Gorgoulis
Laboratory of Histology-Embryology
Chair of Clinical Molecular Pathology, Ninewells Hospital and School of Medicine
University of Dundee, Dundee, UK
Biomedical Research Foundation of the Academy of Athens
Faculty Institute for Cancer Sciences, University of Manchester, Manchester Centre for Cellular Metabolism,
EMBO member
European Academy
Academia Europaea member
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