SenTraGor: a novel reagent to detect senescent cells

Design and synthesis of a novel chemical compound linked with biotin to detect senescent cells. (a) Overview of a pioneering method for senescent cell detection exploiting the specific reaction with lipofuscin of a novel chemical compound (GL13) linked with biotin. Beyond the histochemical capability of these compounds to stain senescent cells, the presence of biotin allows as a second-step application of an enhancing immunohistochemical-enzymatic detection reaction that provides increased sensitivity and recognition precision. (b) Structure of biotin and its particular moieties. (c) Synthesis of compound GL13 (commercially available as SenTraGor). 

1) Evangelou et al. Robust, universal biomarker assay to detect senescent cells in biological specimens. Aging Cell 2017, 16(1): 192-197.

2) Myrianthopoulos et al. Senescence and senotherapeutics: a new field in cancer therapy. Pharmacol Ther 2019, 193: 31-49.

 

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens

 

Biomedical Research Foundation of the Academy of Athens

 

Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester

 

EMBO member

 

SenTraGorΤΜ

 

 

 

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E-mail: vgorg@med.uoa.gr

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