Cellular senescence and cardiovascular diseases

Cellular senescence has been the subject of focused research for over two decades, however it was not until recently that the role of senescence in cardiovascular disease (CVD) started to be explored. A body of evidence has shown that cellular senescence constitutes a stress-mediated pathophysiological mechanism implicated in a wide range of CVDs at the cellular and molecular level. In this review, we recapitulate key molecular and clinical findings supporting the involvement of senescence in heart disease and discuss current clinical strategies aimed at eradicating the detrimental effects of senescence on cardiac homeostasis. Based on recent evidence, we additionally address how the advent of the senotherapeutics field, in conjunction with the development of novel senescence detection tools in tissues and biological fluids may now facilitate effectively combating CVDs.

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens

 

 

Chair of Clinical Molecular Pathology,

Ninewells Hospital and School of Medicine

 

University of Dundee, Dundee, UK

 

Biomedical Research Foundation of the Academy of Athens

 

Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester

 

EMBO member

 

European Academy
of Cancer Sciences member

 

Academia Europaea member

 

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Fax: 0030 210-7462340
E-mail: vgorg@med.uoa.gr

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