Implication of senescence in giant cell arteritis

The pathogenic role of cellular senescence in the context of Giant Cell Artiritis (GCA), an age-related, autoinflammatory and autoimmune syndrome has not been addressed before. This study identified a high proportion of senescent cells (mainly fibroblasts and macrophages) with an inflammatory phenotype in GCA arteries. The presence of senescent cells was associated with the tissue inflammatory bulk via IL-6-dependent pathways, suggesting a potential implication of senescence in disease pathogenesis. These results set the ground for the use of senolytic treatments as a possible complementary strategy in the clinical management of GCA.

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens



Chair of Clinical Molecular Pathology,

Ninewells Hospital and School of Medicine


University of Dundee, Dundee, UK


Biomedical Research Foundation of the Academy of Athens


Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester


EMBO member


European Academy
of Cancer Sciences member


Academia Europaea member, 180 Varick Street, 6th Floor, New York, NY 10014, USA 






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