Marilena Papaioanou


ChlR1 protein encoded by the DDX11 gene is currently in the centre of my research activity. It is a protein engaged in different aspects of replication and I am exploring the effects of its deregulation in different cellular backgrounds utilizing inducible human epithelial cell lines. I am particularly focused on genomic instability induced by ChlR1/DDX11 overexpression.


ChlR1/DDX11, replication machinery, DDR, carcinogenesis, genomic instability


Exploring and exploiting the systemic effects of deregulated replication licensing. Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG. Semin Cancer Biol. 2016 Jun;37-38:3-15.

IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity. Bahri R, Pateras IS, D'Orlando O, Goyeneche-Patino DA, Campbell M, Polansky JK, Sandig H, Papaioannou M, Evangelou K, Foukas PG, Gorgoulis VG, Bulfone-Paus S. Oncoimmunology. 2015 Jan 22;4(9):e1002721. eCollection 2015 Sep.

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Gupta J, Igea A, Papaioannou M, Lopez-Casas PP, Llonch E, Hidalgo M, Gorgoulis VG, Nebreda AR. Oncotarget. 2015 Apr 20;6(11):8539-51.

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12.

VG New

Prof. Vassilis G. Gorgoulis

Laboratory of Histology-Embryology
Molecular Carcinogenesis Group
Medical School
National and Kapodistrian University of Athens



Chair of Clinical Molecular Pathology,

Ninewells Hospital and School of Medicine


University of Dundee, Dundee, UK


Biomedical Research Foundation of the Academy of Athens


Faculty Institute for Cancer Sciences, University of Manchester,
Manchester Academic Health Science Centre, Manchester, UK

Manchester Centre for Cellular Metabolism,
University of Manchester, Manchester Academic Health Science Centre, Manchester


EMBO member


European Academy
of Cancer Sciences member


Academia Europaea member, 180 Varick Street, 6th Floor, New York, NY 10014, USA 






Office Tel: 0030 210-7462352
Fax: 0030 210-7462340


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